Elucidating an uncommon disease inflammatory breast cancer ranchosantafedating com
The study included patients and their tumor tissues from Egypt, Tunisia, and Morocco.
The Egyptian patients and their tumor characteristics are included in our previous publications [19,20].
IBC is characterized by a greater metastatic potential and significantly shorter survival than other forms of breast cancer [11,23,34].
The diagnosis of IBC is primarily based on clinical not histopathologic characteristics .
These criteria were determined before beginning the study and before reviewing the pathology reports or finding the paraffin blocks, so in the process of selection, there was no other source of bias introduced at all.
We decided on the criteria that would allow us to answer the scientific question of whether there are significant differences between IBC and non-IBC with regards to the variables studied and included all of the patents who fulfilled these criteria .
Compared to other types of breast cancer, IBC affects younger women, progresses rapidly, and tends to be more advanced at the time of diagnosis [6,33].
Egyptian IBC patients had the highest combined erythema, edema, peau d'orange, and metastasis among the 3 IBC groups. Tumor emboli were more frequent in Egyptian IBC than non-IBC (Mean ± SD: 14.1 ± 14.0 vs.
Egyptian IBC tumors had the highest Rho C expression than Tunisians and Moroccan IBCs (87% vs. 7.0 ± 12.9, respectively) (P Correspondence to: Amr S. Understanding molecular characteristics that distinguish inflammatory breast cancer (IBC) from non-IBC is crucial for elucidating breast cancer etiology and management.
Soliman, Department of Epidemiology, University of Nebraska Medical Center College of Public Health, 984395 Nebraska Medical Center, Omaha, NE 68198-4395, USA. We included 3 sets of patients from Egypt (48 IBC and 64 non-IBC), Tunisia (24 IBC and 40 non-IBC), and Morocco (42 IBC and 41 non-IBC).
Egyptian IBC patients had the highest combined erythema, edema, peau d'orange, and metastasis among the 3 IBC groups. Tumor emboli were more frequent in Egyptian IBC than non-IBC (Mean ±SD: 14.1 ± 14.0 vs. This study illustrates that Rho C overexpression and tumor emboli are more frequent in IBC relative to non-IBC from Egypt and Tunisia.
Bilateral breast involvement was found in 3 patients.