Sedating a patient

Posted by / 21-Mar-2019 22:31

Sedating a patient

Sedation also is an essential therapeutic component of intracranial pressure therapy, targeted temperature management and seizure control.Given the lack of large trials which have evaluated clinically relevant endpoints, sedative selection depends on the effect of each agent on cerebral and systemic haemodynamics.

Second, sedation/analgesia has additional ‘neuro-specific’ indications in the acute phase that might significantly influence its use in this setting [3].

In this review, we provide a concise summary of the main cerebral physiologic effects of sedatives and analgesics, the advantages/disadvantages of each agent, the comparative effects of standard sedatives (mainly propofol and midazolam) in patients with ABI, and the emerging role of alternative sedatives, particularly ketamine.

ICU delirium is not covered here, because no delirium assessment tools have been validated in the ABI population.

In this setting, sedative agents act by reducing CMRO with sedatives is generally dose dependent, until the EEG becomes isoelectric.

Beyond this level, no further suppression of cerebral oxygen consumption can occur, while minimal consumption persists for cellular homeostasis [8, 9].

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In this review, we provide a concise summary of cerebral physiologic effects of sedatives and analgesics, the advantages/disadvantages of each agent, the comparative effects of standard sedatives (propofol and midazolam) and the emerging role of alternative drugs (ketamine).

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  1. He is currently pursuing a Ph D in Ethnomusicology at University Malaya, focusing on the research of the sociocultural and historical background of the Southeast Asian art song, particularly the Malaysian Chinese art song.